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KMID : 0379520040200020153
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한국독성학회지
2004 Volume.20 No. 2 p.153 ~ p.158
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Genotoxicity Study of CJ-11555
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Park Jie-Eun
Lee Sung-Hak
Choi Jae-Mook
Kim Il-Hwan
Kim Deog-Yeor
Noh Hyun-Jung
Kim Taek-Rho
Kim Young-Hoon
Lim Jee-Woong
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Abstract
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To evaluate the genotoxicity of CJ-11555, an anti-cirrhotic agent, the reverse mutation test, chromosomal aberration test and in vivo micronucleus test in rats were performed. In the reverse mutation test, the treatment of CJ-11555 at doses of 33.3, 100, 333, 1000, 3330 and 5000 mutextrm{g}/plate with and without 89 did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537, and Escherichia coli (E. call) WP2uvrA. In chromosomal aberration test, CJ-11555 did not induce structural a chromosomal aberration in Chinese hamster ovary (CHO) cells with and without metabolic activation at all doses. In micronucleus test, CJ-11555 did not induce any statistically significant increases in micronucleated polychromatic erythrocyte (MNPCE) at doses of 500, 1000, and 2000 mg/kg. These results suggest that CJ-11555 might not have a mutagenic potential under the conditions in this study.
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KEYWORD
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Genotoxicity, CJ-11555, Anti-cirrhotic agent, Reverse mutation, Chromosomal aberration, Micronucleus.
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